The South African retired archbishop and Nobel peace laureate will challenge G4S's management over the company's role in facilitating "Israel's brutal occupation and abhorrent prison system" at the company's annual general meeting in London on Thursday afternoon.
Tutu, and several other notable protesters including directors Mike Leigh and Ken Loach, philosopher Noam Chomsky and barrister Michael Mansfield QC, have written an open letter to G4S management, published in the Guardian, demanding the company stop supplying equipment to Israeli prisons.
"G4S helps the Israeli Prison Service to run prisons inside Israel that hold prisoners from occupied Palestinian territory, despite the Fourth Geneva Convention prohibition of the transfer of prisoners from occupied territory into the territory of the occupier," the protesters wrote.
"Through its involvement in Israel's prison system, G4S is complicit in violations of international law and participates in Israel's use of mass incarceration as a means by which to dissuade Palestinians from protesting Israel's systematic human rights abuses."
The protesters said that human rights organizations have documented "systematic torture" and ill treatment of Palestinian prisoners, including children held in solitary confinement, at some of the Prisons.
In a separate letter to the Guardian a number of MPs, including Jeremy Corbyn and Joan Ruddock, said children were reportedly ill-treated in the prisons and called on G4S to "terminate its contracts with facilities where children suffer routine physical and verbal abuse".
G4S, which employs 8,000 in Israel, said it "takes very seriously our obligations to ensure that our activities do not contribute to human rights abuses".
This week the UK government's National Contact Point watchdog launched an investigation into G4S's activities in Israel and the West Bank. The National Contact Point, which is part of the department for Business, said it had "accepted issues for further examination". It follows a formal complaint by Lawyers for Palestinian Human Rights, a charity that has long criticised G4S.
The Bill and Melinda Gates Foundation Trust recently reduced its stake in G4S after British campaign group War on Want wrote to Gates to urge him to sell the stake because of the company's activities in Israel. The Gates foundation declined to comment on the reasons behind the sale.